Repairing Process Models with Non-Free-Choice Constructs Based on Token Replay

A method of repairing process models with non-free-choice constructs is proposed based on logical Petri nets, aiming at the problem of low precision in the existing repair methods. An extended successor matrix of transitions is determined according to the distance between any two transitions. There are two types of choice-construct transitions. One is a non-free-choice construct transition, and the other is a general choice construct transition. The type of choice-construct transitions can be determined based on the extended successor matrix and the relationship between the front and back sets of transitions. The location of the deviations is calculated by an improved replaying method. Finally, a model can be repaired according to remaining-token places and missing-token places. Based on the experiments on real event logs, the method proposed in this paper has a better performance in fitness, precision, and simplicity compared with its peers

The TRAPs From Microglial Vesicles Protect Against Listeria Infection in the CNS

Previous studies have demonstrated that T cells and microglia could fight against cerebral Listeria monocytogenes (Listeria); however, their synergistic anti-Listeria mechanisms remain unknown. Following Listeria infection in a culture system, we found that microglia, but not nerve cells, could release extracellular traps (ETs) which originated from microglial vesicles. Specific inhibitor analysis showed that extracellular DNA (eDNA), matrix metallopeptidases (MMP9 and MMP12), citrullinated histone H3, and peptidyl arginine deiminase 2 were the major components of microglial ETs (MiETs) and were also the components of vesicles. Systematic analysis indicated that Listeria-induced MiETs were cytosolic reactive oxygen species (ROS)- and NADPH oxidase (NOX)-dependent and involved ERK. MiETs were exhibited in Listeria-infected mouse brain and might protected against Listeria infection via bacterial killing in a mouse meningitis model, and MiETs existed in cerebrospinal fluid (CSF) from Listeria meningitis patients in vivo and in vitro. Additionally, interferon-γ could induce MiET formation in Listeria-infected microglia in vitro that was mediated by NOX, and there was a positive relationship between the elevated level of IFN-γ and eDNA and nucleosomes in the brain homogenates and CSF of Listeria meningitis model mice and in the CSF before treatment in clinical Listeria meningitis patients. Together, this is the first report of MiET formation, these findings pave the way for deeper exploration of the innate immune response to pathogens in CNS

Overview of Researches on Social Capital, Human Capital and Social Integration of New Generation Migrant Workers

With urbanization and socio-economic development, new generation migrant workers play an increasingly important role in urban construction. However, for a long time, their social integration situation in inflow places is not ideal. Academic circle has done a lot of researches, but no effective strategy is so far put forward. Through analysis of domestic and foreign researches, it is found that social capital and human capital have an important influence on social integration of new generation migrant workers. This paper takes this as starting point, combines characteristics of new generation migrant workers, and overviews theories and empirical researches of domestic and foreign famous scholars, to explore the relationship between social capital and human capital and social integration of new generation migrant workers

Double-Cycling AGV Scheduling Considering Uncertain Crane Operational Time at Container Terminals

Container terminals (CTs) play an important role in the modern logistics and transportation industry. The utilization of automated guided vehicles (AGVs) can be effectively facilitated by reducing their empty running. The existing strategies cannot guarantee the full load of AGVs during their transportation because of the complex constraints of container scheduling. This work proposes a double-cycling AGV scheduling model that ensures a full load of AGVs between the quayside and the yard. The objective is to minimize the total waiting time of AGVs and ensure a high loading rate of AGVs by scheduling loading/unloading containers. Furthermore, it takes the randomness of the quay crane’s operational time into consideration. By assigning a time interval to AGVs’ arrival at a quayside, a container scheduling sequence is obtained based on a Hybrid Particle Swarm Optimization (HPSO) algorithm with a penalty function. Via experiments, it shows that the proposed model can obtain the least number of AGVs for container transportation, minimize AGVs’ total waiting time, and ensure the high loading rate of AGVs

ZrC–ZrB2–SiC ceramic nanocomposites derived from a novel single-source precursor with high ceramic yield

Abstract For the first time, ZrC–ZrB2–SiC ceramic nanocomposites were successfully prepared by a single-source-precursor route, with allylhydridopolycarbosilane (AHPCS), triethylamine borane (TEAB), and bis(cyclopentadienyl) zirconium dichloride (Cp2ZrCl2) as starting materials. The polymer-to-ceramic transformation and thermal behavior of obtained single-source precursor were characterized by means of Fourier transform infrared spectroscopy (FT-IR) and thermal gravimetric analysis (TGA). The results show that the precursor possesses a high ceramic yield about 85% at 1000 °C. The phase composition and microstructure of formed ZrC–ZrB2–SiC ceramics were investigated by means of X-ray diffraction (XRD) and high resolution transmission electron microscopy (HRTEM). Meanwhile, the weight loss and chemical composition of the resultant ZrC–ZrB2–SiC nanocomposites were investigated after annealing at high temperature up to 1800 °C. High temperature behavior with respect to decomposition as well as crystallization shows a promising high temperature stability of the formed ZrC–ZrB2–SiC nanocomposites

Alginate Oligosaccharide Ameliorates D-Galactose-Induced Kidney Aging in Mice through Activation of the Nrf2 Signaling Pathway

Aging is an independent risk factor for the development of age-related progressive kidney injury. As a part of the aging process, kidney aging has been indicated to be associated with oxidative stress-induced damage. Ameliorating oxidative damage is therefore considered a promising strategy for delaying kidney aging. Alginate oligosaccharide (AOS) has been reported to have a wide range of biological and pharmacological activities. However, no studies have focused on the role of AOS in delaying the kidney aging process. In this study, we aimed to evaluate the potential effects of AOS on kidney aging and its possible mechanisms. Subcutaneous injection of D-galactose (D-gal) (200 mg·kg-1·d-1) in C57BL/6J mice for 8 weeks was used to establish the aging model. AOS (200 mg·kg-1·d-1) was administered via oral gavage for the last four weeks. As a result, AOS inhibited the D-gal-induced upregulation of aging markers and significantly improved the kidney index and kidney function of D-gal-induced mice. In addition, AOS ameliorated the degree of tissue damage and fibrosis in the aging kidney. To further explore the potential mechanisms by which AOS attenuates the kidney aging process, the associated oxidative stress-induced damage was analyzed in depth. The data showed that AOS upregulated the expression of Klotho and decreased malondialdehyde levels by increasing the expression of antioxidant enzymes. Furthermore, our results suggested that AOS activated the nuclear factor erythrogen-2 associated factor 2 (Nrf2) pathway by promoting Nrf2 nuclear translocation in aging mice and upregulated the downstream expression of heme oxygenase-1 (HO-1) and NADPH quinone oxidoreductase 1 (NQO1). In conclusion, the present study demonstrated that AOS is a promising agent for attenuating kidney aging, and the underlying molecular mechanisms are related to the activation of the Nrf2 signaling pathway

S1 Data -

Widespread vaccination against important diseases plays a key role for global health security, particularly in the context of the COVID-19 pandemic. However, building and maintaining trust in immunization services remains challenging because of doubts about quality and safety of vaccines. China has periodically faced mounting pressure and even public outrage triggered by incidents of poor-quality vaccines. We aimed to evaluate the impact of the diphtheria, pertussis, and tetanus (DPT) vaccine scandal of 2018 in China and the ensuing misinformation on vaccination, and investigate differential responses to the scandal by ethnic and socioeconomic factors. With data from January 2017 to December 2018 in Sichuan province, China, we used a difference-in-differences (DID) method to compare the changes in the county-level monthly DPT vaccinations against the hepatitis B vaccinations, both before and after the DPT vaccine scandal. We found that the number of DPT vaccinations decreased by 14.0 percent in response to the vaccine scandal and ensuing misinformation. The number of vaccinations in minority regions, under-developed regions, and regions with poor medical resources decreased more than in non-minority regions, developed regions, and regions with good medical resources (24.5 versus 10.1 percent, 17.3 versus 8.3 percent, and 17.0 versus 8.7 percent, respectively). People did more online searching for “Substandard vaccine” and “DPT vaccine” after the scandal, with the socioeconomically advantaged group searching more compared with the socioeconomically disadvantaged group. The results suggest the urgent need to make true information about the vaccine easily accessible over the internet, especially for the socioeconomically disadvantaged groups. Our findings for China can also have implications for immunization service planning for better safeguarding public health in other countries, particularly developing ones.</div

Parallel trends assumption check for number of vaccinations.

Parallel trends assumption check for number of vaccinations.</p